C-terminal fragment of APP interacts with p62, forms an aggregate

p62 app  p62SQSTM1 to modulate S et al Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin  The selective autophagy substrate p62 serves as a molecular link between autophagy and cancer Suppression of autophagy causes p62 accumulation and thereby

Application Key: WB-Western Blotting Species Cross-Reactivity Key: H-Human; M SQSTM1p62 Antibody detects endogenous levels of total SQSTM1p62 protein   Overproduction In humans, the loss of p62 caused damages to the central nervous system without other organs affected

macular degeneration and cancer in animals, and the possible application of p62 plasmid in other inflammation-associated diseases  APPPS1 Transgenic Mice Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System